The Cassandra Crossing
George P. Cosmatos
Tom Mankiewicz (screenplay), Robert Katz (story and screenplay)
Sophia Loren as Jennifer Rispoli Chamberlain, Richard Harris as Dr. Jonathan Chamberlain, Martin Sheen as Robby Navarro, Burt Lancaster as Colonel Stephen Mackenzie, Ava Gardner as Nicole Dressler
"Passengers on a European train have been exposed to a deadly disease. Nobody will let them off the train. So what happens next?"
Note: This is NOT about the woman in this series. Since the name is almost the same, I mention it here ONLY to let everyone know there is nothing to know. That and the movie had Sophie Loren which is enough to warrant mentioning anytime.